dearJulius.com Write For Us

First esophagus grown from stem cells transplanted into mice

While it is too early to know if the method could work for humans, researchers say it may help for treatment of the birth defect esophageal atresia in infants.

Researchers for the first time have grown a functional esophagus from stem cells and transplanted it successfully in mice, which they think could one day be used to treat cases of Esophageal atresia. Photo by Alena Ozerova

By Allen Cone, UPI

Researchers for the first time have grown a functional esophagus from stem cells and transplanted the food pipe successfully in mice.

This engineering process could pave the way to the creation of lab-grown food pipes for children with congenital and acquired gut conditions, according to researchers at the University of College London's Great Ormond Street Institute of Child Health.

The development could help reduce the need for donated organs, which are often in short supply -- especially for pediatric patients -- and significantly lowers the risk of a donor organ being rejected by the patient's body.

A paper on the work, conducted by researchers at UCL, as well as the Great Ormond Street Hospital and the Francis Crick Institute, was published this week in the journal Nature Communications.

"This is a major step forward for regenerative medicine, bringing us ever closer to treatment that goes beyond repairing damaged tissue and offers the possibility of rejection-free organs and tissues for transplant," Dr. Paulo De Coppi, who leads stem cells and regenerative medicine research at ICH and co-lead on the new research, said in a press release. "At GOSH we see a large number of referrals for some of the most complex and rare defects of the gut and though the outlook for children is good, the condition and treatments have long-term implications."

The esophagus is a tube that connects the mouth to the stomach. Esophageal atresia is a birth defect in which part of the esophagus does not develop properly, so infants are unable to pass food from the mouth to the stomach and may have difficulty breathing.

Esophageal atresia affects about 1 in 4,300 pregnancies in the United States, according to the Centers for Disease Control and Prevention.

Researchers used a rat esophagus "scaffold" and human gut cells to grow engineered tubes of esophagus. Within a week of being implanted into mice, the engineered tissue developed its own blood supply, which is important to squeeze down food.

"This is the first time that such a complicated organ has been grown in the lab," said Dr. Paola Bonfanti, a research associate at ICH and co-leader of the study.

She said they had to use multi-step approach to develop a piece of esophagus that resembles and works the same as a normal, human one.

"Not only is the gut tube shaped, but as it also consists of several different layers of cells," he said. "It's truly a promising step forward for children and even adults with esophageal conditions."

De Coppi added that "we're really excited about these promising preclinical findings," but that much more research is necessary before this method can be tested in humans.

COMMENTS





Note: If you think this story need more information or correction, feel free to comment below your opinion and reaction.
Name

Body & Mind,6,Fitness,29,Health,1295,Weight Loss,5,Wellness,6,
ltr
item
Health News: First esophagus grown from stem cells transplanted into mice
First esophagus grown from stem cells transplanted into mice
While it is too early to know if the method could work for humans, researchers say it may help for treatment of the birth defect esophageal atresia in infants.
https://2.bp.blogspot.com/-EjyGPbKZN_A/W8wrrDoiYXI/AAAAAAABEyo/cbUcPr5SDP8vR-fjVgyrSwhUPW9yk_lHQCLcBGAs/s1600/3.jpg
https://2.bp.blogspot.com/-EjyGPbKZN_A/W8wrrDoiYXI/AAAAAAABEyo/cbUcPr5SDP8vR-fjVgyrSwhUPW9yk_lHQCLcBGAs/s72-c/3.jpg
Health News
https://health.dailynewsview.com/2018/10/first-esophagus-grown-from-stem-cells.html
https://health.dailynewsview.com/
https://health.dailynewsview.com/
https://health.dailynewsview.com/2018/10/first-esophagus-grown-from-stem-cells.html
true
2090190010889992275
UTF-8
Loaded All Posts Not found any posts VIEW ALL Read More Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS PREMIUM CONTENT IS LOCKED STEP 1: Share. STEP 2: Click the link you shared to unlock Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy