dearJulius.com Write For Us

Scientists closer to drug that cuts nicotine dependence

A Chinese man smokes a cigarette in Beijing on December 18, 2015. File Photo by Stephen Shaver/UPI

By HealthDay News

Researchers say they've created an enzyme that might one day reduce nicotine cravings in smokers.

The scientists gave the enzyme to nicotine-dependent rats and found it broke down nicotine in the bloodstream before it could reach the brain.

This quickly reduced the rats' nicotine dependence. It also prevented them from relapsing when they again had access to nicotine, according to the study.

"This is a very exciting approach because it can reduce nicotine dependence without inducing cravings and other severe withdrawal symptoms," said principal investigator Olivier George. He's an associate professor at Scripps Research Institute in La Jolla, Calif.

Also, the enzyme "works in the bloodstream, not the brain, so its side-effects should be minimal," George added in an institute news release.

Nicotine dependence is what makes it so difficult for people to quit smoking. Preventing the nicotine in tobacco from reaching the brain has long been seen as a promising way of reducing dependence, but previous efforts haven't resulted in drugs that reduce blood levels of nicotine enough to be effective.

The enzyme tested in this study is called NicA2-J1. It's based on a natural enzyme produced by the bacterium Pseudomonas putida, but was modified to boost its potency, staying time in the blood, and other features to fight nicotine dependence.

The researchers plan to continue to improve the enzyme's properties with the goal of eventually conducting human clinical trials. However, it's important to note that results of animal trials aren't always replicable in humans.

The findings were published online Oct. 17 in Science Advances.

More information
The U.S. Centers for Disease Control and Prevention has more on quitting smoking.

COMMENTS





Note: If you think this story need more information or correction, feel free to comment below your opinion and reaction.
Name

Body & Mind,6,Fitness,29,Health,1268,Weight Loss,5,Wellness,6,
ltr
item
Health News: Scientists closer to drug that cuts nicotine dependence
Scientists closer to drug that cuts nicotine dependence
https://1.bp.blogspot.com/-BMxZpmAmB2E/W8sr1_irgGI/AAAAAAABEqU/ot9p5euUV7gYm4EzFS8AEvsqVo0ZdXdoACLcBGAs/s1600/5.jpg
https://1.bp.blogspot.com/-BMxZpmAmB2E/W8sr1_irgGI/AAAAAAABEqU/ot9p5euUV7gYm4EzFS8AEvsqVo0ZdXdoACLcBGAs/s72-c/5.jpg
Health News
https://health.dailynewsview.com/2018/10/scientists-closer-to-drug-that-cuts.html
https://health.dailynewsview.com/
https://health.dailynewsview.com/
https://health.dailynewsview.com/2018/10/scientists-closer-to-drug-that-cuts.html
true
2090190010889992275
UTF-8
Loaded All Posts Not found any posts VIEW ALL Read More Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS PREMIUM CONTENT IS LOCKED STEP 1: Share. STEP 2: Click the link you shared to unlock Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy