dearJulius.com Write For Us

Widely used antipsychotics may not ease delirium in ICU


By HealthDay News

Two common antipsychotic drugs are ineffective in treating delirium in intensive care unit patients, and don't shorten the length of time spent in the ICU or the hospital, a new study finds.

Despite widespread use of haloperidol or ziprasidone, "we found, after extensive investigation with medical centers all over the country, that the patients who get these potentially dangerous drugs are not experiencing any improvements whatsoever in delirium, coma, length of stay or survival," said senior author Dr. E. Wesley Ely.

He's professor of medicine at Vanderbilt University School of Medicine, in Nashville, Tenn.

"Every day, there are many thousands of patients receiving unnecessary antipsychotics in the critical care setting that are bringing risk and cost without benefit," Ely said in a university news release.

Delirium affects more than 7 million hospitalized Americans a year. It can occur in patients of any age, but is more common among older adults who have a major illness -- especially involving ICU care -- or who have major surgery.

Antipsychotic medications have been used to treat delirium in ICU patients for 40 years. But the new study "suggests the need to reexamine that practice," said Dr. Marie Bernard, deputy director of the U.S. National Institute on Aging, which funded the study. She spoke in an agency news release.

In the new study, Ely's team tracked outcomes for 566 ICU patients treated at 16 U.S. medical centers. All of the patients developed delirium and were given either intravenous haloperidol, ziprasidone or a placebo (saline). The patients had a wide range of ages and conditions.

The researchers observed no significant difference between the three groups in duration of delirium or coma, and no significant differences in 30-day or 90-day death rates, or in time spent on a ventilator, in the ICU, or in the hospital.

There was no evidence that the antipsychotics caused major harm to any patients. However, other studies have found that the drugs do come with risks and are tied to a higher risk of stroke, pneumonia, balance problems and falls in elderly patients.

Dr. Mark Astiz directs critical care medicine at Lenox Hill Hospital in New York City. He said that "patients who are being treated for life-threatening diseases frequently develop a delirium, which is complicated by agitation and behavioral changes."

The new findings are "consistent with earlier smaller clinical trials suggesting that [antipsychotics] should not be routinely used for this indication in critically ill patients," Astiz said.

The study was published online Oct. 22 in the New England Journal of Medicine.

More information
The U.S. National Library of Medicine has more on delirium.

COMMENTS





Note: If you think this story need more information or correction, feel free to comment below your opinion and reaction.
Name

Body & Mind,6,Fitness,29,Health,1268,Weight Loss,5,Wellness,6,
ltr
item
Health News: Widely used antipsychotics may not ease delirium in ICU
Widely used antipsychotics may not ease delirium in ICU
https://4.bp.blogspot.com/-qIpXFeNGgbk/W87UbIWfFqI/AAAAAAABFP8/JlW5gADcxAM8cJ9kOebrdQvSZcfyihlbACLcBGAs/s1600/4.jpg
https://4.bp.blogspot.com/-qIpXFeNGgbk/W87UbIWfFqI/AAAAAAABFP8/JlW5gADcxAM8cJ9kOebrdQvSZcfyihlbACLcBGAs/s72-c/4.jpg
Health News
https://health.dailynewsview.com/2018/10/widely-used-antipsychotics-may-not-ease.html
https://health.dailynewsview.com/
https://health.dailynewsview.com/
https://health.dailynewsview.com/2018/10/widely-used-antipsychotics-may-not-ease.html
true
2090190010889992275
UTF-8
Loaded All Posts Not found any posts VIEW ALL Read More Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS PREMIUM CONTENT IS LOCKED STEP 1: Share. STEP 2: Click the link you shared to unlock Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy