Researchers restore vision in rats after retinal cell transplant

Retinas are the layer at the back of the eye that contain cells sensitive to light and trigger nerve impulses that pass via the optic nerve to the brain, where a visual image is formed.

By Allen Cone, UPI

Transplanted fetal retina cells successfully restored vision in blind rats by restoring neurons in the vision centers of their brains.

Researchers at the University of California, Irvine School of Medicine found that sheets of fetal cells integrated into the retina -- which is in back of the eye -- can generate nearly normal visual activity in their brains. The findings were published Monday in JNeurosci, the Journal of Neuroscience.

"It's been known that retinal sheet transplants can integrate into the degenerated eyes and allow the animals to detect light," Dr. David Lyon, associate professor of anatomy and neurobiology at UCI School of Medicine, said in a press release. "But, beyond rudimentary light detection it was not known how well the visual system in the brain functioned with the newly integrated retinal transplant."

They found that neurons in the primary visual processing center perform as well as neurons in animals with normal healthy retinas

"These results show the great potential of retinal transplants to treat retinal degeneration in people," Lyon said.

An estimated 1.8 million Americans aged 40 years and older are affected by age-related macular degeneration and an additional 7.3 million with white deposits under the retina are at substantial risk of developing AMD, according to the Centers for Disease Control and Prevention. Diabetic retinopathy is the leading cause of blindness in adults in the United States.

Current treatments for age-related macular degeneration and retinitis pigmentosa can only help protect existing cells from further damage and won't work during late stages of disease once these cells are gone.

Retinal sheet transplants have been successful in humans besides animals but their ability to restore complex vision has not yet been assessed.

"Remarkably, we found fetal retinal sheet transplants generated visual responses in cortex similar in quality to normal rats," Lyon said. "The transplants also preserved connectivity within the brain that supports potential of this approach in curing vision loss associated with retinal degeneration."

Three to 10 months after surgery, rats became sensitive to various attributes of visual stimuli, including size, orientation and contrast.


Note: If you think this story need more information or correction, feel free to comment below your opinion and reaction.

Body & Mind,6,Fitness,32,Health,1436,Healthy Living,2,Weight Loss,5,Wellness,7,
Health News: Researchers restore vision in rats after retinal cell transplant
Researchers restore vision in rats after retinal cell transplant
Health News
Loaded All Posts Not found any posts VIEW ALL Read More Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS PREMIUM CONTENT IS LOCKED STEP 1: Share. STEP 2: Click the link you shared to unlock Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy